Sjögrens syndrome—the non-apoptotic model of glandular hypofunction
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چکیده
منابع مشابه
Sjogrens syndrome--the non-apoptotic model of glandular hypofunction.
The ‘classical’ model to explain glandular hypofunction in Sjögrens syndrome (SS) is tissue loss secondary to immune attack mediated by a combination of apoptosis and cytotoxic cell death (reviewed recently by Ramos-Casals and Font [1]). In this model, the process of glandular destruction is made self-sustaining by the continued production of novel ‘self ’ antigens, secondary to apoptotic bleb ...
متن کاملHydroxychloroquine therapy in patients with primary Sjögren's syndrome may improve salivary gland hypofunction by inhibition of glandular cholinesterase.
OBJECTIVE To determine whether (i) cholinesterase activity is increased in the saliva of patients with primary Sjogren's syndrome (pSS), (ii) increased levels of cholinesterase of lymphocyte origin could interfere with the secretory activity of submandibular acinar cells, and (iii) hydroxychloroquine at therapeutic doses could interfere with cholinesterase activity. METHODS The Ellman method ...
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ژورنال
عنوان ژورنال: Rheumatology
سال: 2006
ISSN: 1462-0332,1462-0324
DOI: 10.1093/rheumatology/kel067